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Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use by Shou‐Yen Kao; Cheng‐Hsien Wu; Shu‐Chun Lin; Soon‐Kiong Yap; Che‐Shoa Chang; Yong‐Kie Wong; Lin‐Yang Chi; Tsung‐Yun Liu is a Medicine article available to read on EtoBox.
What is Genetic polymorphism of cytochrome P4501A1 and susceptibility to oral squamous cell carcinoma and oral precancer lesions associated with smoking/betel use about?
## Abstract **Background:** The importance of the __CYP1A1__ polymorphisms at exon 7 (Ile/Val) and 3′‐untranslated region (3′‐UTR) has been controversial in oral squamous cell carcinoma (OSCC) or head and neck SCC (HNSCC) denoting the value of exploring the correlation between these polymorphisms and risk of betel/smoking associated OSCC. It is also important to evaluate the association between __CYP1A1__ polymorphisms and susceptibility of oral precancerous lesion (OPL) to confirm the findings in OSCC cases. **Methods:** We examined polymorphic prevalence of __CYP1A1__ at exon 7 (Ile/Val) and 3′‐UTR in 106 cases with OSCC, 60 cases with OPL, and 146 controls. DNA isolated from surgical specimens and whole blood was used for PCR‐based genotyping. **Results:** The prevalence of the __CYP1A1 A__/__G__ genotype (Ile/Val) and __G__/__G__ genotype (Val/Val) in exon 7 of cases with OSCC (79.2 and 7.6%) and OPL (68.3 and 10%) were significantly higher than in controls (53.4 and 1.4%) (__P__ < 0.0001). The novelty of the present study is that we identified the onset age of OSCC in __CYP1A1 A__/__G__ genotype to be significantly younger than that in __A__/__A__ genotype (__P__ < 0.01). No s
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- Author
- Shou‐Yen Kao; Cheng‐Hsien Wu; Shu‐Chun Lin; Soon‐Kiong Yap; Che‐Shoa Chang; Yong‐Kie Wong; Lin‐Yang Chi; Tsung‐Yun Liu
- Publisher
- John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0904-2512)
- Published
- 2002
- Language
- EN
- Field
- Medicine (Health Sciences)