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What is Huntingtin about?

The study investigates the role of huntingtin (htt) in enhancing the vesicular transport of brain-derived neurotrophic factor (BDNF) along microtubules, which is crucial for neuronal survival and neurotrophic support. It demonstrates that wild-type htt promotes efficient transport of BDNF-containing vesicles, while the pathogenic polyglutamine-expanded form of htt disrupts this process, leading to neurotoxicity associated with Huntington

Author

nevdull

Language

EN