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Allelic Loss in Clinically and Screening‐detected Primary Hyperparathyroidism by Pamela Correa; Christofer Juhlin; Jonas Rastad; Göran Åkerström; Gunnar Westin; Tobias Carling is a Medicine article available to read on EtoBox.

What is Allelic Loss in Clinically and Screening‐detected Primary Hyperparathyroidism about?

## Summary **objective** Parathyroid adenomas frequently harbour deletions of genomic DNA at chromosome regions 1p, 6q and 11q. In this study we related clinical characteristics in 56 patients with primary hyperparathyroidism (pHPT) to loss of heterozygosity (LOH) in these chromosome regions. **design** LOH analysis was performed on 56 sporadic parathyroid tumours using a total of 18 microsatellite markers for chromosome regions 1p, 6q and 11q. LOH was identified, for either radioactive or fluorescent labelled markers, as total absence or reduction of ≥ 50% of the signal intensity of an allele in the tumour DNA __vs.__ constitutional DNA. **patients** Twenty‐one of the patients were recruited by a population‐based screening for pHPT and the remaining pHPT patients were gathered from routine clinical practice. **results** In total, 27%, 23% and 23% of the tumours showed LOH at 1p, 6q and 11q, respectively. LOH at both 1p and 11q was more common in the screening‐detected pHPT patients compared to those recruited from clinical practice (38%__vs.__ 20%; __P__= 0·02 and 43%__vs.__ 11%; __P__= 0·001, respectively), while allelic loss at 6q was more prevalent in the latter group (11%__vs.

Who reads Allelic Loss in Clinically and Screening‐detected Primary Hyperparathyroidism?

Author

Pamela Correa; Christofer Juhlin; Jonas Rastad; Göran Åkerström; Gunnar Westin; Tobias Carling

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley; Research Square (ISSN 0300-0664)

Published

2002

Language

EN

Field

Medicine (Health Sciences)