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This article discusses the use of pooled blood samples to optimize the Youden index and the corresponding cut-point for biomarkers, particularly in the context of high testing costs. It highlights the effectiveness of pooling in reducing costs while maintaining diagnostic accuracy, and presents methods for estimating the Youden index and optimal cut-point under various distributional assumptions. The study emphasizes the importance of balancing sensitivity and specificity in diagnostic testing, especially w

Author

ashwini;jagadeesan

Language

EN