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Can I read Effect of Haemodynamic Pressure Overload of the Adult Ferret Right Ventricle on Inotropic Responsiveness to External Calcium and Rest Periods on EtoBox?
Effect of Haemodynamic Pressure Overload of the Adult Ferret Right Ventricle on Inotropic Responsiveness to External Calcium and Rest Periods by S. Baudet; J. Noireaud; C. Loty is a Medicine article available to read on EtoBox.
What is Effect of Haemodynamic Pressure Overload of the Adult Ferret Right Ventricle on Inotropic Responsiveness to External Calcium and Rest Periods about?
The inotropic effects of external calcium concentration ([Ca2+]o] and rest periods have been compared in papillary muscles isolated from control (n = 4) and pressure-overloaded right (n = 5) ventricles of adult ferrets. Hypertrophy was induced by pulmonary artery clipping for 30-45 days. Under control conditions (3 mM [Ca2+]o, 0.1 Hz), the isometric twitch force of hypertrophied muscles was decreased by 75%, time to peak was increased by 30% and time to half-relaxation was increased by 50% compared with non-hypertrophied preparations. The sensitivity of contraction to [Ca2+]o was decreased in hypertrophied muscles compared with control ([Ca2+] required for half-maximal contraction: 4.1 mM vs 1.7 mM) and the maximal contraction reached at high [Ca2+]o was smaller in pressure-overloaded muscles compared with control (8.3 +/- 2.0 mN mm-2 vs 19.0 +/- 2.1 mN mm-2 respectively). In both groups, rest periods longer than the steady-state interval were initially accompanied by a potentiation of the first post-rest contraction compared with steady-state. Peak potentiation occurred after a rest of 120 s in hypertrophied muscles and after a rest of 60 s in control. The maximal relative potenti
Who reads Effect of Haemodynamic Pressure Overload of the Adult Ferret Right Ventricle on Inotropic Responsiveness to External Calcium and Rest Periods?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- S. Baudet; J. Noireaud; C. Loty
- Publisher
- Springer; Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0031-6768)
- Published
- 1992
- Language
- EN
- Field
- Medicine (Life Sciences)