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Encapsulated Checkpoint Blocker Before Chemotherapy: The Optimal Sequence of Anti-CTLA-4 and Doxil Combination Therapy by Reza Aimohammadi; Razie Alibeigi; Amin Reza Nikpoor; Ghanbar Mahmoodi Chalbatani; Thomas J Webster; Mahmoud Reza Jaafari; Seyed Amir Jalali is a Materials Science article available to read on EtoBox.

What is Encapsulated Checkpoint Blocker Before Chemotherapy: The Optimal Sequence of Anti-CTLA-4 and Doxil Combination Therapy about?

## Introduction Today, a new paradigm has emerged for cancer treatment introducing combination therapies. Doxil, a liposomal doxorubicin serving as a chemotherapeutic agent, is an effective immunogenic killer of cancer cells. Anti-CTLA-4 has been approved for the treatment of some cancers, including melanoma, but side effects have limited its therapeutic potential. ## Methods In this study, two approaches were utilized to increase treatment efficiency and decrease the side effects of anti-CTLA-4, combining it with chemotherapy and encapsulation in a PEGylated liposome. A different sequence of anti-CTLA-4 and Doxil was assessed in combination therapy using non-liposomal and liposomal anti-CTLA-4. ## Results Our results showed that liposomal anti-CTLA-4 reduced the size of established tumors and increased survival in comparison with non-liposomal anti-CTLA-4 in a well-established B16 mouse melanoma model. In combination therapy with Doxil, only the administration of anti-CTLA-4 before Doxil showed synergism in both non-liposomal and liposomal form and increased the CD8^+^/regulatory T cell ratio. ## Discussion In summary, our results demonstrate the potential of utilizing a nanocarri

Who reads Encapsulated Checkpoint Blocker Before Chemotherapy: The Optimal Sequence of Anti-CTLA-4 and Doxil Combination Therapy?

Author

Reza Aimohammadi; Razie Alibeigi; Amin Reza Nikpoor; Ghanbar Mahmoodi Chalbatani; Thomas J Webster; Mahmoud Reza Jaafari; Seyed Amir Jalali

Published

2020

Language

EN

Field

Materials Science (Physical Sciences)