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Can I read Withdrawal of immunosuppressants and low-dose steroids in patients with stable IgG4-RD (WInS IgG4-RD): an investigator-initiated, multicentre, open-label, randomised controlled trial on EtoBox?
Withdrawal of immunosuppressants and low-dose steroids in patients with stable IgG4-RD (WInS IgG4-RD): an investigator-initiated, multicentre, open-label, randomised controlled trial by Linyi Peng; Yuxue Nie; Jiaxin Zhou; Lijun Wu; Xiaomei Chen; Fang Wang; Jieqiong Li; Yu Peng; Hui Lu; Lidan Zhao; Mengtao Li; Yan Zhao; Xiaofeng Zeng; Yunyun Fei; Wen Zhang is a Medicine article available to read on EtoBox.
What is Withdrawal of immunosuppressants and low-dose steroids in patients with stable IgG4-RD (WInS IgG4-RD): an investigator-initiated, multicentre, open-label, randomised controlled trial about?
## Objectives IgG4-related disease (IgG4-RD) is an immune-mediated, fibroinflammatory disease. Induction treatment with glucocorticoid (GC) is usually effective, but its tendency of relapse makes the strategy for maintenance treatment a challenge. The WInS IgG4-RD (withdraw immunosuppressants (IMs) and steroid in stable IgG4-RD) trial tested whether discontinuation of GC and IM was feasible in stable IgG4-RD. ## Methods The WInS IgG4-RD trial was a multicentre, open-label, randomised controlled trial. Patients with IgG4-RD receiving GC+IM as maintenance treatment with clinically quiescent disease for at least 12 months were randomised (1:1:1) into three groups: group 1: withdraw GC+IM; group 2: withdraw GC but maintain IM; group 3: maintain GC+IM. The primary outcome was the relapse rate of disease within 18 months. The secondary outcomes included the changes of IgG4-RD Responder Index (RI), Physician’s Global Assessment (PGA), serum IgG4 and IgG, as well as adverse events. ## Results One hundred and forty-six patients were randomised, with 48 patients in group 1, 49 patients in group 2 and group 3, respectively. Within the 18-month follow-up period, disease relapse occurred in 25
Who reads Withdrawal of immunosuppressants and low-dose steroids in patients with stable IgG4-RD (WInS IgG4-RD): an investigator-initiated, multicentre, open-label, randomised controlled trial?
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- Author
- Linyi Peng; Yuxue Nie; Jiaxin Zhou; Lijun Wu; Xiaomei Chen; Fang Wang; Jieqiong Li; Yu Peng; Hui Lu; Lidan Zhao; Mengtao Li; Yan Zhao; Xiaofeng Zeng; Yunyun Fei; Wen Zhang
- Publisher
- BMJ
- Published
- 2024
- Language
- EN
- Field
- Medicine (Health Sciences)