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Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial by Karoline Aker; Niranjan Thomas; Lars Adde; Beena Koshy; Miriam Martinez-Biarge; Ingeborg Nakken; Caroline S Padankatti; Ragnhild Støen is a Medicine article available to read on EtoBox.

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## Objective To evaluate the accuracy of neonatal MRI and general movements assessment (GMA) in predicting neurodevelopmental outcomes in infants with hypoxic-ischaemic encephalopathy (HIE). ## Design Secondary analyses of a randomised controlled trial (RCT). ## Setting Tertiary neonatal intensive care unit in India. ## Methods Fifty infants with HIE were included in an RCT of therapeutic hypothermia (25 cooled and 25 non-cooled). All infants underwent brain MRI at day 5, GMA at 10–15 weeks and outcome assessments including Bayley Scales of Infant and Toddler Development, third edition, at 18 months. Associations between patterns of brain injury, presence/absence of fidgety movements (FMs) and outcomes were assessed. ## Results Seventeen of 47 (36%) had adverse outcome (5 (21%) cooled vs 12 (52%) non-cooled, p=0.025). Eight infants died (four before an MRI, another three before GMA). Two developed severe cerebral palsy and seven had Bayley-III motor/cognitive composite score <85. Twelve (26%) had moderately/severely abnormal MRI and nine (23%) had absent FMs. The positive predictive value (95% CI) of an adverse outcome was 89% (53% to 98%) for moderate/severe basal ganglia and thal

Who reads Prediction of outcome from MRI and general movements assessment after hypoxic-ischaemic encephalopathy in low-income and middle-income countries: data from a randomised controlled trial?

Author

Karoline Aker; Niranjan Thomas; Lars Adde; Beena Koshy; Miriam Martinez-Biarge; Ingeborg Nakken; Caroline S Padankatti; Ragnhild Støen

Publisher

BMJ

Published

2021

Language

EN

Field

Medicine (Health Sciences)