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The impact of proteinase-induced matrix degradation on the release of VEGF from heparinized collagen matrices by Chang Yao; Martin Roderfeld; Timo Rath; Elke Roeb; Jürgen Bernhagen; Guy Steffens is a Engineering article available to read on EtoBox.
What is The impact of proteinase-induced matrix degradation on the release of VEGF from heparinized collagen matrices about?
The in vivo application of engineered matrices in human wound healing processes is often hampered by the slow rate of vascularization. Therefore much research is directed towards enhancing the angiogenic properties of such matrices. One approach for enhancing the vascularization is the incorporation of angiogenic growth factors. Recently, we and others have reported on immobilizing such factors into collagen matrices either by covalent attachment or by physical binding to covalently incorporated heparin. Especially the latter procedure has been shown to lead to substantial increase rates in vascularization in in vivo experiments. The increases have been proposed to depend on the sustained release of the incorporated angiogenic growth factors from the heparinized collagen matrices. In this paper, we report on investigations to study the release of vascular endothelial growth factor (VEGF) from collagen matrices under conditions which mimic potential in vivo situations. Relevant proteinase concentrations were deduced from in vitro experiments in which we evaluated the secretion of selected matrix metalloproteinases from fibroblasts in contact with collagen. The release of VEGF from n
Who reads The impact of proteinase-induced matrix degradation on the release of VEGF from heparinized collagen matrices?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Chang Yao; Martin Roderfeld; Timo Rath; Elke Roeb; Jürgen Bernhagen; Guy Steffens
- Publisher
- Elsevier Science; Elsevier ; Elsevier Ltd.; Elsevier BV (ISSN 0142-9612)
- Published
- 2006
- Language
- EN
- Field
- Engineering (Physical Sciences)