Can I read Ketamine and fMRI BOLD signal: Distinguishing between effects mediated by change in blood flow versus change in cognitive state on EtoBox?

Ketamine and fMRI BOLD signal: Distinguishing between effects mediated by change in blood flow versus change in cognitive state by Kathryn M. Abel; Matthew P.G. Allin; Katarzyna Kucharska‐Pietura; Chris Andrew; Steve Williams; Anthony S. David; Mary L. Phillips is a scholarly article available to read on EtoBox.

What is Ketamine and fMRI BOLD signal: Distinguishing between effects mediated by change in blood flow versus change in cognitive state about?

## Abstract No human fMRI studies have examined ketamine effects on the BOLD signal change associated with cognitive task performance. We wished to distinguish between effects on 1) cerebral blood flow, with resultant change in BOLD signal; and 2) cognition and neural mechanisms underlying BOLD signal change associated with task performance. Eight right‐handed men (mean age 28.75 years) received ketamine or saline i.v. in a randomized, double‐blind manner (bolus 0.23 mg/kg; 0.5 mg/kg over 45 min to a maximum 1 hr). Subjects viewed 10 alternating 30‐sec blocks of faces with neutral expressions and a fixation cross and discriminated gender of faces. Gradient echo echoplanar images were acquired on a GE Signa 1.5 T Neurovascular system. One hundred T2‐weighted images depicting BOLD contrast were acquired over 5 min (for each task) at each of 14 near‐axial noncontiguous 7‐mm thick planes. Ketamine significantly increased dissociative phenomena and negative symptoms, but did not affect performance of the gender discrimination task. Significant BOLD signal change was demonstrated predominantly in occipitotemporal cortex with both ketamine and placebo. Only two clusters in middle occipita

Author

Kathryn M. Abel; Matthew P.G. Allin; Katarzyna Kucharska‐Pietura; Chris Andrew; Steve Williams; Anthony S. David; Mary L. Phillips

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley; Research Square (ISSN 1065-9471)

Published

2002

Language

EN