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Acute Effects of Cannabis on Speech Illusions and Psychotic-like Symptoms: Two Studies Testing the Moderating Effects of Cannabidiol and Adolescence by Claire Mokrysz; Natacha D. C. Shaban; Tom P. Freeman; Will Lawn; Rebecca A. Pope; Chandni Hindocha; Abigail Freeman; Matthew B. Wall; Michael A. P. Bloomfield; Celia J. A. Morgan; David J. Nutt; H. Valerie Curran is a Medicine article available to read on EtoBox.
What is Acute Effects of Cannabis on Speech Illusions and Psychotic-like Symptoms: Two Studies Testing the Moderating Effects of Cannabidiol and Adolescence about?
## Abstract ## Background Acute cannabis administration can produce transient psychotic-like effects in healthy individuals. However, the mechanisms through which this occurs and which factors predict vulnerability remain unclear. We investigate whether cannabis inhalation leads to psychotic-like symptoms and speech illusion; and whether cannabidiol (CBD) blunts such effects (study 1) and adolescence heightens such effects (study 2). ## Methods Two double-blind placebo-controlled studies, assessing speech illusion in a white noise task, and psychotic-like symptoms on the Psychotomimetic States Inventory (PSI). Study 1 compared effects of Cann-CBD (cannabis containing Δ-9-tetrahydrocannabinol (THC) and negligible levels of CBD) with Cann+CBD (cannabis containing THC and CBD) in 17 adults. Study 2 compared effects of Cann-CBD in 20 adolescents and 20 adults. All participants were healthy individuals who currently used cannabis. ## Results In study 1, relative to placebo, both Cann-CBD and Cann+CBD increased PSI scores but not speech illusion. No differences between Cann-CBD and Cann+CBD emerged. In study 2, relative to placebo, Cann-CBD increased PSI scores and incidence of speech il
Who reads Acute Effects of Cannabis on Speech Illusions and Psychotic-like Symptoms: Two Studies Testing the Moderating Effects of Cannabidiol and Adolescence?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Claire Mokrysz; Natacha D. C. Shaban; Tom P. Freeman; Will Lawn; Rebecca A. Pope; Chandni Hindocha; Abigail Freeman; Matthew B. Wall; Michael A. P. Bloomfield; Celia J. A. Morgan; David J. Nutt; H. Valerie Curran
- Publisher
- Cambridge University Press; Cambridge University Press (CUP) (ISSN 0033-2917)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Social Sciences)