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In vitro Biological Performances of Phosphorylcholine‐Grafted ePTFE Prostheses through RFGD Plasma Techniques by Pascale Chevallier; Richard Janvier; Diego Mantovani; Gaétan Laroche is a Materials Science article available to read on EtoBox.

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## Abstract **Summary:** Arterial prostheses made of microporous Teflon® (ePTFE) are currently used in vascular surgery as bypasses for small and medium vessels. However, several clinical complications, such as thrombosis, frequently occur in these prostheses when implanted in humans. In this work, an original strategy was developed to improve the hemocompatibility of ePTFE prostheses, based on glow‐discharge surface modification followed by chemical grafting of phosphorylcholine, known for its hemocompatible properties. This procedure leads to a covalent attachment of the molecules, therefore preventing their removal by shear stress induced by blood flow at the implant wall. The improvement of the blood compatibility properties of the modified ePTFE arterial prostheses have been investigated by in vitro tests such as thromboelastography, neutrophil adsorption, platelet aggregation, and cell cultures. These in vitro tests put in evidence that thrombogenicity index, platelet aggregation, and neutrophil adhesion were decreased by the molecule grafted on the prostheses. Moreover, the cell growth on the surface of the PRC‐grafted prostheses was greatly enhanced in comparison to the vir

Who reads In vitro Biological Performances of Phosphorylcholine‐Grafted ePTFE Prostheses through RFGD Plasma Techniques?

Author

Pascale Chevallier; Richard Janvier; Diego Mantovani; Gaétan Laroche

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Ltd.; Wiley (ISSN 1616-5187)

Published

2005

Language

EN

Field

Materials Science (Physical Sciences)