Opening book details…
Can I read Molecular detection of blaCTX-M gene to predict phenotypic cephalosporin resistance and clinical outcome of Escherichia coli bloodstream infections in Vietnam on EtoBox?
Molecular detection of blaCTX-M gene to predict phenotypic cephalosporin resistance and clinical outcome of Escherichia coli bloodstream infections in Vietnam by Trinh Van Son; Nguyen Dang Manh; Ngo Tat Trung; Dao Thanh Quyen; Christian G. Meyer; Nguyen Thi Kim Phuong; Phan Quoc Hoan; Vu Viet Sang; Dennis Nurjadi; Thirumalaisamy P. Velavan; Mai Hong Bang; Le Huu Song is a Medicine article available to read on EtoBox.
What is Molecular detection of blaCTX-M gene to predict phenotypic cephalosporin resistance and clinical outcome of Escherichia coli bloodstream infections in Vietnam about?
## Abstract ## Background Blood stream infections (BSI) caused by Extended Spectrum Beta-Lactamases (ESBLs) producing Enterobacteriaceae is a clinical challenge leading to high mortality, especially in developing countries. In this study, we sought to describe the epidemiology of ESBL-producing Escherichia coli strains isolated from Vietnamese individuals with BSI, to investigate the concordance of genotypic-phenotypic resistance, and clinical outcome of ESBL E. coli BSI. ## Methods A total of 459 hospitalized patients with BSI were screened between October 2014 and May 2016. 115 E. coli strains from 115 BSI patients were isolated and tested for antibiotic resistance using the VITEK®2 system. The ESBL phenotype was determined by double disk diffusion method following the guideline of Clinical and Laboratory Standards Institute. Screening for beta-lactamase (ESBL and carbapenemase) genes was performed using a multiplex-PCR assay. ## Results 58% (67/115) of the E. coli strains were ESBL-producers and all were susceptible to both imipenem and meropenem. Resistance to third-generation cephalosporin was common, 70% (81/115) were cefotaxime-resistant and 45% (52/115) were ceftazidime-res
Who reads Molecular detection of blaCTX-M gene to predict phenotypic cephalosporin resistance and clinical outcome of Escherichia coli bloodstream infections in Vietnam?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Trinh Van Son; Nguyen Dang Manh; Ngo Tat Trung; Dao Thanh Quyen; Christian G. Meyer; Nguyen Thi Kim Phuong; Phan Quoc Hoan; Vu Viet Sang; Dennis Nurjadi; Thirumalaisamy P. Velavan; Mai Hong Bang; Le Huu Song
- Publisher
- Springer Science and Business Media LLC
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)