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Polyamidoamine dendrimer-PEG hydrogel and its mechanical property on differentiation of mesenchymal stem cells by Xiangdong Bi; Panita Maturavongsadit; Yu Tan; Morgan Watts; Evelyn Bi; Zachary Kegley; Steve Morton; Lin Lu; Qian Wang; Aiye Liang is a Medicine article available to read on EtoBox.
What is Polyamidoamine dendrimer-PEG hydrogel and its mechanical property on differentiation of mesenchymal stem cells about?
## Background: Biocompatible hydrogel systems with tunable mechanical properties have been reported to influence the behavior and differentiation of mesenchymal stem cells (mscs). ## Objective: To develop a functionalized hydrogel system with well-defined chemical structures and tunable mechanical property for regulation of stem cell differentiation. ## Methods: An in situ-forming hydrogel system is developed by crosslinking vinyl sulfone functionalized polyamidoamine (pamam) dendrimer and multi-armed thiolated polyethylene glycol (peg) through a thiol-ene michael addition in aqueous conditions. the viability and differentiation of mscs in hydrogels of different stiffness are conducted for 21 days under corresponding induction media. ## Results: Mscs are viable in synthesized hydrogels after 48 hours of culture. by varying the concentrations of pamam dendrimer and peg, hydrogels of different gelation time and stiffness are achieved. the msc differentiation indicates that more osteogenic differentiation is observed in hard gel (5,663 pa) and more adipogenic differentiation is observed in soft gel (77 pa) in addition to the differentiation caused by each individual induction media du
Who reads Polyamidoamine dendrimer-PEG hydrogel and its mechanical property on differentiation of mesenchymal stem cells?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Xiangdong Bi; Panita Maturavongsadit; Yu Tan; Morgan Watts; Evelyn Bi; Zachary Kegley; Steve Morton; Lin Lu; Qian Wang; Aiye Liang
- Publisher
- IOS Press
- Published
- 2018
- Language
- EN
- Field
- Medicine (Health Sciences)