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Can I read In situ sensors for blood-brain barrier (BBB) on a chip on EtoBox?
In situ sensors for blood-brain barrier (BBB) on a chip by Yan Liang; Jeong-Yeol Yoon is a Engineering article available to read on EtoBox.
What is In situ sensors for blood-brain barrier (BBB) on a chip about?
The blood-brain barrier (BBB) is critical for the central nervous system, as its integrity protects neurons and other brain cells from harmful toxicants and disease-associated molecules, while it also blocks the delivery of therapeutic drugs to brain. Understanding the function and physiology of BBB have made slow progress due to the relative lack of effective models. Microfluidic BBB-on-a-chip models have gained attentions recently through recreating a more accessible, in vivo-like microenvironments. Although many fabrication and application methods have been demonstrated and improved for BBB-on-a-chip, the detection methods used in those systems seem to heavily reply on conventional analytical instruments, which are bulky, expensive, time-consuming, and not suitable for large-scale industrial operations. The TEER (transendothelial electrical resistance) measurement has become popular for identifying the integrity of BBB due to its compatibility, noninvasiveness, and rapid readings. While the TEER sensor has been a major success in BBB-on-a-chip, this may be the only major in situ sensor that have been successfully incorporated in BBB-on-a-chip models. In this review paper, we (1)
Who reads In situ sensors for blood-brain barrier (BBB) on a chip?
It is typically read by researchers, students, and practitioners in Engineering.
- Author
- Yan Liang; Jeong-Yeol Yoon
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Engineering (Physical Sciences)