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Role of Divalent Cations in HIV-1 Replication and Pathogenicity by Khan, Nabab; Chen, Xuesong; Geiger, Jonathan D. is a Medicine article available to read on EtoBox.

What is Role of Divalent Cations in HIV-1 Replication and Pathogenicity about?

Divalent cations are essential for life and are fundamentally important coordinators of cellular metabolism, cell growth, host-pathogen interactions, and cell death. Specifically, for human immunodeficiency virus type-1 (HIV-1), divalent cations are required for interactions between viral and host factors that govern HIV-1 replication and pathogenicity. Homeostatic regulation of divalent cations’ levels and actions appear to change as HIV-1 infection progresses and as changes occur between HIV-1 and the host. In people living with HIV-1, dietary supplementation with divalent cations may increase HIV-1 replication, whereas cation chelation may suppress HIV-1 replication and decrease disease progression. Here, we review literature on the roles of zinc (Zn^2+^), iron (Fe^2+^), manganese (Mn^2+^), magnesium (Mg^2+^), selenium (Se^2+^), and copper (Cu^2+^) in HIV-1 replication and pathogenicity, as well as evidence that divalent cation levels and actions may be targeted therapeutically in people living with HIV-1.

Who reads Role of Divalent Cations in HIV-1 Replication and Pathogenicity?

Author

Khan, Nabab; Chen, Xuesong; Geiger, Jonathan D.

Publisher

MDPI AG; Multidisciplinary Digital Publishing Institute (MDPI); Basel: MDPI, 2009- (ISSN 1999-4915)

Published

2020

Language

EN

Field

Medicine (Health Sciences)