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This study investigates the role of natural killer (NK) cells in systemic juvenile idiopathic arthritis (sJIA) by analyzing their gene expression and functionality. Findings indicate that NK cells from sJIA patients exhibit an altered gene expression profile with increased inflammatory markers but intact cytotoxic function, alongside defects in granzyme K expression and IL-18-induced IFN-γ production. These alterations may contribute to the immune dysregulation observed in sJIA, highlighting the importance

Author

uygunumut847

Language

EN