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This study examined how insulin-induced expression of the enzyme hexokinase II (HKII) is affected in obesity and type 2 diabetes (NIDDM). The researchers found that: 1) Insulin stimulation of HKII mRNA expression and activity was reduced in obese and NIDDM subjects compared to lean controls. 2) Total HKII activity was lower in obese subjects and further reduced in NIDDM subjects relative to controls. 3) Reduced HKII expression may contribute to the decreased insulin-stimulated glucose uptake observed in mu

Author

Umarani Mohanasundaram

Language

EN