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Can I read Photo-crosslinked GelMA/collagen membrane loaded with lysozyme as an antibacterial corneal implant on EtoBox?
Photo-crosslinked GelMA/collagen membrane loaded with lysozyme as an antibacterial corneal implant by Xiangjing Yang; Xiaomin Sun; Jia Liu; Yongrui Huang; Yuehai Peng; Yingni Xu; Li Ren is a Materials Science article available to read on EtoBox.
What is Photo-crosslinked GelMA/collagen membrane loaded with lysozyme as an antibacterial corneal implant about?
Corneal transplantation is an effective treatment for corneal blindness. However, it brings risk factors for the occurrence of bacterial keratitis, which can affect the repair effect and even lead to transplantation failure. The difficulty in re-epithelialization is also a main problem faced by corneal transplantation. Herein, a collagen-GelMA composite membrane containing lysozyme (CGL) was developed as an antibacterial corneal implant to fill stromal defect and support re-epithelialization. Characterizations of physicochemical properties and in vitro biocompatibility revealed that the composite membranes have proper water content, light transmittance and mechanical strength as well as good biocompatibility. Particularly, the cell adhesion force and adhesion-related genes expression were evaluated and exhibited an improvement after the addition of GelMA. Furthermore, the formed CGL membrane could continuously release lysozyme and exhibited a bactericidal rate of 96% and 64% after 2 h and 72 h, respectively. The results demonstrated that this CGL membrane has promising application in corneal repair.
Who reads Photo-crosslinked GelMA/collagen membrane loaded with lysozyme as an antibacterial corneal implant?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Xiangjing Yang; Xiaomin Sun; Jia Liu; Yongrui Huang; Yuehai Peng; Yingni Xu; Li Ren
- Publisher
- Elsevier BV
- Published
- 2021
- Language
- EN
- Field
- Materials Science (Physical Sciences)