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Stereotactic Radiotherapy in the Treatment of Juxtapapillary Choroidal Melanoma: Preliminary Results by Khaled Emara; Daniel J Weisbrod; Arjun Sahgal; Hugh McGowan; Satish Jaywant; Howard Michaels; David Payne; Melania Pintilie; Normand J Laperriere; E.Rand Simpson is a Medicine article available to read on EtoBox.

What is Stereotactic Radiotherapy in the Treatment of Juxtapapillary Choroidal Melanoma: Preliminary Results about?

Purpose: To evaluate the preliminary results of stereotactic radiotherapy in the management of patients with juxtapapillary choroidal melanoma. Methods & Materials: A retrospective, consecutive case series of 28 patients with choroidal melanoma located within 2 mm of the optic nerve who were treated with stereotactic radiotherapy at Princess Margaret Hospital, Toronto, between October 1998 and May 2001. Results: Median age was 62 years. Median tumor height was 4.6 mm and median maximum tumor diameter was 9.4 mm. The prescribed radiation dose was 70 Gy in five fractions over 10 days and median follow-up was 18.5 months. Posttreatment, 2 patients developed local tumor regrowth and 3 patients developed liver metastases. Actuarial rates of local tumor control, metastases, and survival at 18 months were 96%, 10%, and 94%, respectively. Actuarial rates of radiation-induced neovascular glaucoma, cataract, retinopathy, and optic neuropathy at 18 months were 20%, 29%, 30%, and 37%, respectively. A higher radiation dose to the lens was associated with an increased risk of cataract (p ‫؍‬ 0.02). Conclusions: Stereotactic radiotherapy offers a noninvasive alternative to enucleation and brachyt

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Author

Khaled Emara; Daniel J Weisbrod; Arjun Sahgal; Hugh McGowan; Satish Jaywant; Howard Michaels; David Payne; Melania Pintilie; Normand J Laperriere; E.Rand Simpson

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

2004

Language

EN

Field

Medicine (Health Sciences)