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Bisphosphonates Impair the Onset of Bone Formation at Remodeling Sites by Jensen, Pia Rosgaard (author);Andersen, Thomas Levin (author);Chavassieux, Pascale (author);Roux, Jean-Paul (author);Delaisse, Jean-Marie (author) is a Medicine article available to read on EtoBox.

What is Bisphosphonates Impair the Onset of Bone Formation at Remodeling Sites about?

Bisphosphonates are widely used anti-osteoporotic drugs targeting osteoclasts. They strongly inhibit bone resorption, but also strongly reduce bone formation. This reduced formation is commonly ascribed to the mechanism maintaining the resorption/formation balance during remodeling. The present study provides evidence for an additional mechanism where bisphosphonates actually impair the onset of bone formation after resorption. The evidence is based on morphometric parameters recently developed to assess the activities reversing resorption to formation. Herein, we compare these parameters in cancellous bone of alendronate- and placebo-treated postmenopausal osteoporotic patients. Alendronate increases the prevalence of eroded surfaces characterized by reversal cells/osteoprogenitors at low cell density and remote from active bone surfaces. This indicates deficient cell expansion on eroded surfaces - an event that is indispensable to start formation. Furthermore, alendronate decreases the coverage of these eroded surfaces by remodeling compartment canopies, a putative source of reversal cells/osteoprogenitors. Finally, alendronate strongly decreases the activation frequency of bone

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Author

Jensen, Pia Rosgaard (author);Andersen, Thomas Levin (author);Chavassieux, Pascale (author);Roux, Jean-Paul (author);Delaisse, Jean-Marie (author)

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)