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In vitro evaluation of orthopedic composite cytotoxicity: Assessing the potential for postsurgical production of hydroxyl radicals by Michael DiCicco; Ryan Compton; Susan A. Jansen-Varnum is a Medicine article available to read on EtoBox.

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## Abstract Hydroxyl radical (·OH)‐induced inflammation is a primary mode for __in vivo__ cytotoxicity. A legitimate concern is whether particulate wear debris from orthopedic composites can stimulate inflammation via ferrous ion (Fe^2+^)‐mediated production of ·OH. The purpose of this research was to utilize electron paramagnetic resonance (EPR) spin trapping in investigating and comparing the potential for postsurgical cytotoxicity induced specifically by ·OH in the presence of two composites: Simplex P® and the novel, hybrid, CORTOSSTM. Cytotoxicity is evaluated based on the composites competitively chelating catalytic Fe^2+^ or readily reducing ferric ions (Fe^3+^), in facilitating the Fenton reaction (FR). ·OH that are produced were then validated by a radical scavenger to confirm a genuine radical signal and mechanism. Spin adduct peak areas decreased in the presence of CORTOSS as opposed to increasing in the presence of Simplex P, evaluated against their respective controls. A plausible theory elucidating this finding is that CORTOSS may sequester the Fe form, by virtue of its monomers. Principally, direct comparison of composites indicated that Simplex P had greater tendenc

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Author

Michael DiCicco; Ryan Compton; Susan A. Jansen-Varnum

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); Heterocorporation; Wiley (ISSN 0021-9304)

Published

2004

Language

EN

Field

Medicine (Health Sciences)