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Tenuifolin Ameliorates the Sleep Deprivation‐induced Cognitive Deficits by Ning Jiang; Yiwen Zhang; Caihong Yao; Yupei Liu; Yuzhen Chen; Fang Chen; Yan Wang; Muhammad Iqbal Choudhary; Xinmin Liu is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

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## Abstract Tenuifolin (TEN), a natural neuroprotective compound obtained from the __Polygala tenuifolia__ Willd plant, has improved cognitive symptoms. However, the impact of TEN on memory impairments caused by sleep deprivation (SD) is unclear. Accordingly, the objective of this study was to investigate the mechanisms behind the preventative benefits of TEN on cognitive impairment caused by SD. TEN (10 and 20 mg/kg) and Huperzine A (0.1 mg/kg) were given to mice through oral gavage for 28 days during the SD process. The results indicate that TEN administrations improve short‐ and long‐term memory impairments caused by SD in the Y‐maze, object identification, and step‐through tests. Moreover, TEN stimulated the generation of anti‐inflammatory cytokines (interleukin‐10), lowered the production of pro‐inflammatory cytokines (interleukin‐1β, interleukin‐6, and interleukin‐18), and activated microglia, improving antioxidant status in the hippocampus. TEN treatments significantly boosted the expression of nuclear factor erythroid 2‐related factor 2 and heme oxygenase‐1 while considerably decreasing the expression of NOD‐like receptor thermal protein domain associated protein 3 and casp

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Author

Ning Jiang; Yiwen Zhang; Caihong Yao; Yupei Liu; Yuzhen Chen; Fang Chen; Yan Wang; Muhammad Iqbal Choudhary; Xinmin Liu

Publisher

Wiley

Published

2023

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)