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Both Prediabetes and Type 2 Diabetes Are Associated With Lower Heart Rate Variability: The Maastricht Study by Charlotte Coopmans; Tan Lai Zhou; Ronald M.A. Henry; Jordi Heijman; Nicolaas C. Schaper; Annemarie Koster; Miranda T. Schram; Carla J.H. van der Kallen; Anke Wesselius; Robert J.A. den Engelsman; Harry J.G.M. Crijns; Coen D.A. Stehouwer is a Medicine article available to read on EtoBox.
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## OBJECTIVE Low heart rate variability (HRV), a marker for cardiac autonomic dysfunction, is a known feature of type 2 diabetes, but it remains incompletely understood whether this also applies to prediabetes or across the whole glycemic spectrum. Therefore, we investigated the association among prediabetes, type 2 diabetes, and measures of glycemia and HRV. ## RESEARCH DESIGN AND METHODS In the population-based Maastricht Study (n = 2,107; mean ± SD age 59 ± 8 years; 52% men; normal glucose metabolism [n = 1,226], prediabetes [n = 331], and type 2 diabetes [n = 550, oversampled]), we determined 24-h electrocardiogram-derived HRV in time and frequency domains (individual z-scores, based upon seven and six variables, respectively). We used linear regression with adjustments for age, sex, and major cardiovascular risk factors. ## RESULTS After adjustments, both time and frequency domain HRV were lower in prediabetes and type 2 diabetes as compared with normal glucose metabolism (standardized β [95% CI] for time domain: −0.15 [−0.27; −0.03] and −0.34 [−0.46; −0.22], respectively, P for trend <0.001; for frequency domain: −0.14 [−0.26; −0.02] and −0.31 [−0.43; −0.19], respectively, P
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- Author
- Charlotte Coopmans; Tan Lai Zhou; Ronald M.A. Henry; Jordi Heijman; Nicolaas C. Schaper; Annemarie Koster; Miranda T. Schram; Carla J.H. van der Kallen; Anke Wesselius; Robert J.A. den Engelsman; Harry J.G.M. Crijns; Coen D.A. Stehouwer
- Publisher
- American Diabetes Association; Publons (ISSN 0149-5992)
- Published
- 2020
- Language
- EN
- Field
- Medicine (Health Sciences)