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EnzymeDetector: an integrated enzyme function prediction tool and database by Susanne Quester; Dietmar Schomburg is a Biochemistry, Genetics and Molecular Biology article available to read on EtoBox.

What is EnzymeDetector: an integrated enzyme function prediction tool and database about?

## Background The ability to accurately predict enzymatic functions is an essential prerequisite for the interpretation of cellular functions, and the reconstruction and analysis of metabolic models. Several biological databases exist that provide such information. However, in many cases these databases provide partly different and inconsistent genome annotations. ## Description We analysed nine prokaryotic genomes and found about 70% inconsistencies in the enzyme predictions of the main annotation resources. Therefore, we implemented the annotation pipeline EnzymeDetector. This tool automatically compares and evaluates the assigned enzyme functions from the main annotation databases and supplements them with its own function prediction. This is based on a sequence similarity analysis, on manually created organism-specific enzyme information from BRENDA (Braunschweig Enzyme Database), and on sequence pattern searches. ## Conclusions EnzymeDetector provides a fast and comprehensive overview of the available enzyme function annotations for a genome of interest. The web interface allows the user to work with customisable weighting schemes and cut-offs for the different prediction meth

Who reads EnzymeDetector: an integrated enzyme function prediction tool and database?

Author

Susanne Quester; Dietmar Schomburg

Publisher

BioMed Central; Springer (Biomed Central Ltd.); [London]: BioMed Central, [2000]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2105)

Published

2011

Language

EN

Field

Biochemistry, Genetics and Molecular Biology (Life Sciences)