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Hyperpolarized Lithium‐6 as a Sensor of Nanomolar Contrast Agents by Ruud B. van Heeswijk; Kai Uffmann; Arnaud Comment; Fiodar Kurdzesau; Chiara Perazzolo; Cristina Cudalbu; Sami Jannin; Jacobus A. Konter; Patrick Hautle; Ben van den Brandt; Gil Navon; Jacques J. van der Klink; Rolf Gruetter is a Medicine article available to read on EtoBox.

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## Abstract Lithium is widely used in psychotherapy. The ^6^Li isotope has a long intrinsic longitudinal relaxation time __T__~1~ on the order of minutes, making it an ideal candidate for hyperpolarization experiments. In the present study we demonstrated that lithium‐6 can be readily hyperpolarized within 30 min, while retaining a long polarization decay time on the order of a minute. We used the intrinsically long relaxation time for the detection of 500 nM contrast agent in vitro. Hyperpolarized lithium‐6 was administered to the rat and its signal retained a decay time on the order of 70 sec in vivo. Localization experiments imply that the lithium signal originated from within the brain and that it was detectable up to 5 min after administration. We conclude that the detection of submicromolar contrast agents using hyperpolarized NMR nuclei such as ^6^Li may provide a novel avenue for molecular imaging. Magn Reson Med, 2009. © 2009 Wiley‐Liss, Inc.

Who reads Hyperpolarized Lithium‐6 as a Sensor of Nanomolar Contrast Agents?

Author

Ruud B. van Heeswijk; Kai Uffmann; Arnaud Comment; Fiodar Kurdzesau; Chiara Perazzolo; Cristina Cudalbu; Sami Jannin; Jacobus A. Konter; Patrick Hautle; Ben van den Brandt; Gil Navon; Jacques J. van der Klink; Rolf Gruetter

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0740-3194)

Published

2009

Language

EN

Field

Medicine (Health Sciences)