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Association of chronic hepatitis B virus infection with preterm birth: our experience and meta-analysis by Ai-Min Cui; Jian-Guo Shao; Hai-Bo Li; Yi Shen; Zhi-Xian Chen; Sheng Zhang; Zhao-Lian Bian; Gang Qin; Xiao-Yan Cheng is a Medicine article available to read on EtoBox.
What is Association of chronic hepatitis B virus infection with preterm birth: our experience and meta-analysis about?
## Abstract ## Objectives: To assess the association of chronic hepatitis B virus (HBV) infection with preterm birth (PTB). ## Methods: A cohort of 20,498 pregnant women (497 HBV carriers with 20,001 non-HBV controls) with normal alanine aminotransferase (ALT) levels was selected from the Obstetrics & Gynecology Hospital of Nantong University. The clinical parameters and PTB incidence were compared between HBV carriers and non-HBV subjects. For the meta-analysis, we searched the PubMed, Ovid and Cochrane Library databases for studies comparing PTB incidence between individuals with chronic HBV infection and non-HBV subjects. ## Results: HBV carriers were slightly older and had slightly higher ALT levels within normal limits. The body mass index, education and history of pregnancy between HBV carrier and non-HBV groups were comparable. PTB incidence was not associated with HBV carrier status [relative risk (RR) 0.98, 95% confidence interval (CI) 0.71–1.37] in our cohort. However, the meta-analysis involving eight published studies and our study revealed a significant association between chronic HBV infection and PTB incidence (pooled RR 1.26, 95% CI 1.19–1.33). ## Conclusion: While
Who reads Association of chronic hepatitis B virus infection with preterm birth: our experience and meta-analysis?
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- Author
- Ai-Min Cui; Jian-Guo Shao; Hai-Bo Li; Yi Shen; Zhi-Xian Chen; Sheng Zhang; Zhao-Lian Bian; Gang Qin; Xiao-Yan Cheng
- Publisher
- Walter de Gruyter GmbH
- Published
- 2016
- Language
- EN
- Field
- Medicine (Health Sciences)