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Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease by Ruksana Azhu Valappil; Jed E. Black; Meredith J. Broderick; Oscar Carrillo; Eric Frenette; Shannon S. Sullivan; Samuel M. Goldman; Caroline M. Tanner; James W. Langston is a Medicine article available to read on EtoBox.
What is Exploring the electrocardiogram as a potential tool to screen for premotor Parkinson's disease about?
## Abstract The aim of this study was to test the hypothesis that patients with REM sleep behavior disorder, many of whom will develop Parkinson's disease (PD) or a related synucleinopathy, will demonstrate decreased heart rate variability (HRV) compared with a group of age‐matched controls as measured by an electrocardiogram during wakefulness. We compared HRV in 11 untreated idiopathic REM sleep behavior disorder patients (9 men and 2 women; mean age, 63.3 years; SD, 7.5 years) and 11 control subjects with idiopathic insomnia without REM sleep behavior disorder (7 men and 4 women; mean age, 59.5 years; SD, 8.7 years). Subjects with other causes of reduced HRV were excluded. HRV was determined from 5‐minute presleep segments of a single channel electrocardiogram recorded during polysomnographic evaluations, using R‐R intervals during wakefulness. Time domain, geometric measures, and spectral analysis of the R‐R intervals were significantly different between cases and controls. A discriminant function analysis correctly classified 95.5% of subjects (overall model fit, __P__ = 0.016). Leave‐one‐out cross‐validation correctly classified 77.3% of subjects. HRV during wakefulness is si
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- Author
- Ruksana Azhu Valappil; Jed E. Black; Meredith J. Broderick; Oscar Carrillo; Eric Frenette; Shannon S. Sullivan; Samuel M. Goldman; Caroline M. Tanner; James W. Langston
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0885-3185)
- Published
- 2010
- Language
- EN
- Field
- Medicine (Health Sciences)