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Sharp-edge-based Acoustofluidic Chip for Programmable Pumping, Mixing, Cell Focusing and Trapping by Pavlic, Alen; Harshbarger, Cooper Lars; Rosenthaler, Luca; Snedeker, Jess Gerrit; Dual, Jürg is a scholarly article available to read on EtoBox.

What is Sharp-edge-based Acoustofluidic Chip for Programmable Pumping, Mixing, Cell Focusing and Trapping about?

Precise manipulation of fluids and objects on the micro scale is seldom a simple task, but nevertheless crucial for many applications in life sciences and chemical engineering. We present a microfluidic chip fabricated in silicon-glass, featuring one or several pairs of acoustically excited sharp edges at side channels that drive a pumping flow throughout the chip and produce a strong mixing flow in their vicinity. The chip is simultaneously capable of focusing cells and microparticles that are suspended in the flow. The multifunctional micropump provides a continuous flow across a wide range of excitation frequencies (80kHz-2MHz), with flow rates ranging from nL/min to $\mu$L/min, depending on the excitation parameters. In the low-voltage regime, the flow rate depends quadratically on the voltage applied to the piezoelectric transducer, making the pump programmable. The behaviour in the system is elucidated with finite element method simulations, which are in good agreement with experimentally observed behaviour. The acoustic radiation force arising due to a fluidic channel resonance is responsible for the focusing of cells and microparticles, while the streaming produced by the p

Author

Pavlic, Alen; Harshbarger, Cooper Lars; Rosenthaler, Luca; Snedeker, Jess Gerrit; Dual, Jürg

Published

2022

Language

EN