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Can I read Comprehensive Preclinical Assessment of ADVM-022, an Intravitreal Anti-VEGF Gene Therapy for the Treatment of Neovascular AMD and Diabetic Macular Edema on EtoBox?
Comprehensive Preclinical Assessment of ADVM-022, an Intravitreal Anti-VEGF Gene Therapy for the Treatment of Neovascular AMD and Diabetic Macular Edema by Claire M. Gelfman; Ruslan Grishanin; Kristina Oresic Bender; Aivan Nguyen; Judith Greengard; Pallavi Sharma; Julio Nieves; Szilárd Kiss; Mehdi Gasmi is a Medicine article available to read on EtoBox.
What is Comprehensive Preclinical Assessment of ADVM-022, an Intravitreal Anti-VEGF Gene Therapy for the Treatment of Neovascular AMD and Diabetic Macular Edema about?
Inhibition of vascular endothelial growth factor is the mode of action for several approved therapies, including aflibercept, for the treatment of neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME). Lack of compliance due to the frequent intravitreal dosing requirements may result in inadequately treated disease, leading to irreversible vision impairment. To date, the majority of gene therapy clinical trials providing sustained anti-VEGF levels in the retina have been limited to subretinal injections requiring a vitrectomy. A single intravitreal injection of a gene therapy product could drastically reduce the treatment burden and improve visual outcomes. ADVM-022, an adeno-associated virus vector encoding aflibercept, has been optimized for intravitreal delivery and strong protein expression. Long-term expression and efficacy of ADVM-022-derived aflibercept were evaluated in a laser-induced choroidal neovascularization (CNV) model in non-human primates. Ocular safety was evaluated following long-term suppression of VEGF by clinical scoring (inflammatory parameters) as well as optical coherence tomography (OCT) and electroretinography (ERG). Intravi
Who reads Comprehensive Preclinical Assessment of ADVM-022, an Intravitreal Anti-VEGF Gene Therapy for the Treatment of Neovascular AMD and Diabetic Macular Edema?
It is typically read by researchers, students, and practitioners in Medicine.
- Author
- Claire M. Gelfman; Ruslan Grishanin; Kristina Oresic Bender; Aivan Nguyen; Judith Greengard; Pallavi Sharma; Julio Nieves; Szilárd Kiss; Mehdi Gasmi
- Publisher
- Mary Ann Liebert, Inc., publishers
- Published
- 2021
- Language
- EN
- Field
- Medicine (Health Sciences)