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Can I read Stimulation of Energy Metabolism by α‐Adrenergic Agonists in Primary Cultures of Astrocytes on EtoBox?
Stimulation of Energy Metabolism by α‐Adrenergic Agonists in Primary Cultures of Astrocytes by K. V. Subbarao; Dr. L. Hertz is a Neuroscience article available to read on EtoBox.
What is Stimulation of Energy Metabolism by α‐Adrenergic Agonists in Primary Cultures of Astrocytes about?
Noradrenaline effects on glucose oxidation were studied in primary cultures of astrocytes. C 0 2 formation from labeled glucose was enhanced in the presence of noradrenaline. The stimulatory effect by noradrenaline was exerted both on lactate formation (-20%) and on tricarboxylic acid activity (CO, production from glutamate) (-40%). The effect was, at least partly, exerted on the alpha-ketoglutarate dehydrogenase step. The EC,, value for noradrenaline on lactate formation was significantly lower (60 nM) than that on oxidative metabolism (1,900 nM). Studies with specific adrenergic agonists and antagonists showed that various receptor subtypes are involved. Thus, the effect on lactate formation was mediated exclusively by stimulation of an alpha, receptor whereas oxidative metabolism was enhanced by both alpha, and alpha, receptor stimulation. No effects were exerted by beta receptor agonists or antagonists.
Who reads Stimulation of Energy Metabolism by α‐Adrenergic Agonists in Primary Cultures of Astrocytes?
It is typically read by researchers, students, and practitioners in Neuroscience.
- Author
- K. V. Subbarao; Dr. L. Hertz
- Publisher
- John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0360-4012)
- Published
- 1991
- Language
- EN
- Field
- Neuroscience (Life Sciences)