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Systemic active immunotherapy is shifting from the middle ages to a renaissance period: II. Experimental models for cancer systemic immunotherapy and immunoprophylaxis by G. Mathé; L. Olsson is a Immunology and Microbiology article available to read on EtoBox.

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This is a basic and general question for medical pathophysiology, therapeutics, and especially pharmacologic therapeutics, which was the title of a symposium organized by the Section of Comparative Medicine of the Royal Society of Medicine in 1977 [6]. The synthetic answer is 'yes', since much progress in medicine has been accomplished owing to experimental work on laboratory animals, but the answers to the many problems which arise when comparing the results in animal models and in man, or when comparing the results obtained in different experimental models, or even when rejecting the use of therapeutic materials or methods, because they do not work in standard animal screening, are multiple. After 20 years of experimentation and 10 years of clinical trials in cancer immunotherapy, having at our disposal hundreds of animal experiments in which systemic immunotherapy works [see 13], and a dozen clinical randomized trials in which it gives a significant benefit in the present actuarial analysis [2, 14, 23], while there are some in which it has given no benefit [see 24], it is time to consider, as critically as possible, the value of the experimental models which have been used. Of c

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Author

G. Mathé; L. Olsson

Publisher

Springer-Verlag; Springer Verlag; Springer Science and Business Media LLC (ISSN 0340-7004)

Published

1979

Language

EN

Field

Immunology and Microbiology (Life Sciences)