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Obestatin/ghrelin ratio: A new activity index in inflammatory bowel diseases by Efstratios Alexandridis; Athanasios Zisimopoulos; Nikolaos Liratzopoulos; Ioannis Katsos; Konstantinos Manolas; Georgios Kouklakis is a Medicine article available to read on EtoBox.

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## Background: The aim was to determine obestatin and ghrelin serum levels and their ratio in inflammatory bowel disease (IBD) patients. ## Methods: We measured the ghrelin and obestatin levels of 31 Crohn's disease patients and 22 patients with ulcerative colitis using a radioimmunoassay method. Circulating levels of the 2 hormones and their ratio were correlated with the disease type and activity, disease localization, and treatment. ## Results: The mean ghrelin value was statistically significantly higher in patients with active disease (402.4 AE 462.6 pg/mL) than in patients in remission (148.2 AE 59.6 pg/mL) P 1⁄4 0.0290, a 1⁄4 0.05, whereas obestatin mean values were not (217.4 AE 59.8 pg/ mL in active disease and 189.0 AE 46.8 pg/mL in patients with inactive disease P 1⁄4 0.0607). When we evaluated the obestatin/ ghrelin ratio between active and inactive disease, it was found that the ratio in active disease was statistically significantly lower (0.8 AE 0.3) than in patients in remission (1.4 AE 0.3) P < 0.001, a 1⁄4 0.05. There is also a statistically significantly correlation between obestatin/ghrelin ratio and disease activity (P < 0,001). Conclusions: Ghrelin and obestat

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Author

Efstratios Alexandridis; Athanasios Zisimopoulos; Nikolaos Liratzopoulos; Ioannis Katsos; Konstantinos Manolas; Georgios Kouklakis

Publisher

John Wiley and Sons; Oxford University Press; Oxford University Press (OUP) (ISSN 1078-0998)

Published

2009

Language

EN

Field

Medicine (Health Sciences)