Can I read Plastin 3 Enhances TrkB in SMA on EtoBox?

Plastin 3 Enhances TrkB in SMA by Ngọc Hân Lâm is a document available to read on EtoBox.

What is Plastin 3 Enhances TrkB in SMA about?

The study investigates the role of Plastin 3 (PLS3) in spinal muscular atrophy (SMA), highlighting its ability to rescue the translocation and activation of the Tropomyosin receptor kinase B (TrkB) in motoneurons. It finds that PLS3 improves F-actin dynamics, which is crucial for TrkB activation by brain-derived neurotrophic factor (BDNF), thereby enhancing calcium transients in SMA axon terminals. The research suggests that PLS3 may play a significant role in supporting motoneuron development and function

Author

Ngọc Hân Lâm

Language

EN