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Can I read Mixed-valence Pt(0)/Pt2+ nanoassemblies as high-Z radiosensitizers and metallo-immune regulators for potent radiotherapy of breast cancer on EtoBox?
Mixed-valence Pt(0)/Pt2+ nanoassemblies as high-Z radiosensitizers and metallo-immune regulators for potent radiotherapy of breast cancer by Fan Zhang; Liwen Feng; Changchang Jia; Yingjian Wu; Jie Liu; Xintao Shuai; Zhong Cao is a Materials Science article available to read on EtoBox.
What is Mixed-valence Pt(0)/Pt2+ nanoassemblies as high-Z radiosensitizers and metallo-immune regulators for potent radiotherapy of breast cancer about?
Platinum (Pt)-based high-Z metallic nanoassemblies are admittedly effective radiosensitizers for radiotherapy. The preparation of metallic nanoassemblies with supramolecular self-assembly approach depends on the use of a metal-organic framework or coordination polymer (CP) as a template, which brings about challenges of removing template, controlling nanoassembly size and sufficiently loading Pt to obtain high catalytic efficiency essential for radiosensitizers. Herein, a novel synthetic strategy for fabricating metallic nanoassemblies was developed by introducing an imine group and reducing moiety into the metal-organic CPs, resulting in a reversible redox property. Owing to the nanoconfinement ability of this redox-labile CP template, a one-step synthetic pathway allows the formation of mixed-valence Pt nanoassemblies (PNAs) [Pt(0)/Pt2+] that spontaneously encapsulate high-density and small-sized Pt nanoparticles in the CP template. The PNAs not only catalyze the hydrogen peroxide into oxygen but also release Pt ions in the tumor environment, thus simultaneously exhibits radiosensitization to improve the radiodynamic therapy and activates an antitumor immune response. Meanwhile,
Who reads Mixed-valence Pt(0)/Pt2+ nanoassemblies as high-Z radiosensitizers and metallo-immune regulators for potent radiotherapy of breast cancer?
It is typically read by researchers, students, and practitioners in Materials Science.
- Author
- Fan Zhang; Liwen Feng; Changchang Jia; Yingjian Wu; Jie Liu; Xintao Shuai; Zhong Cao
- Publisher
- Elsevier BV
- Published
- 2023
- Language
- EN
- Field
- Materials Science (Physical Sciences)