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Modular and Customized Fabrication of 3D Functional Microgels for Bottom-Up Tissue Engineering and Drug Screening by Yang, Wenguang; Cai, Shuxiang; Chen, Yibao; Liang, Wenfeng; Lai, Youbin; Yu, Haibo; Wang, Yuechao; Liu, Lianqing is a Engineering article available to read on EtoBox.

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However, given the fact that spatial organization of cells with specific morphological, electrophysiological, and biochemical properties is a defining feature of native biological tissues, the traditional top-down approach poses two main limitations: lack of tunable external morphology and inability to create functional histoarchitectures. [2] These limitations, however, can be addressed by bottom-up strategies, which entail assembling cell-laden modules to create a larger 3D spatially organized construct toward a functional tissue. A number of bottom-up strategies have been proposed by researchers. S. Tasoglu et al. utilized a magnetic micro-robot controlled by magnetic field to manipulate cell-laden hydrogels for achieving 3D tissue assembly. [3] Y. Li et al. generated spatially-controlled heterogeneous 3D microenvironment arrays using surface wettability techniques. [4] F. Xu et al. developed a non-invasive assembler based on acoustic waves to generate multi-layer tissue constructs. [5] N. Mekhileri et al. combined a fluidic delivery system with an injecting printer to form hybrid tissue-engineered constructs. [6] Other assembly technologies that allow for bottom-up tissue engin

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Author

Yang, Wenguang; Cai, Shuxiang; Chen, Yibao; Liang, Wenfeng; Lai, Youbin; Yu, Haibo; Wang, Yuechao; Liu, Lianqing

Publisher

Wiley (John Wiley & Sons); Wiley-Blackwell; Wiley (ISSN 2365-709X)

Published

2020

Language

EN

Field

Engineering (Physical Sciences)