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1) Sulfonamides and DHFR inhibitors work by inhibiting folic acid synthesis in bacteria. They are selective for bacteria because mammalian cells utilize a different pathway. 2) When combined as potentiated sulfonamides, they have a synergistic bactericidal effect through inhibition of both dihydropteroate synthase and dihydrofolate reductase. 3) They have a broad spectrum of activity and are used to treat various bacterial infections. However, they also carry risks of toxicity like crystalluria and bone ma

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Dhaif dhaif

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EN