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Activity‐ and age‐dependent GABAergic synaptic plasticity in the developing rat hippocampus by Paolo Gubellini; Yehezkel Ben‐Ari; Jean‐Luc Gaïarsa is a Neuroscience article available to read on EtoBox.

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## Abstract Activity‐dependent plasticity of GABAergic synaptic transmission was investigated in rat hippocampal slices obtained between postnatal day (P) 0–15 using the whole‐cell patch‐clamp recording technique. Spontaneous GABA~A~ receptor‐mediated postsynaptic currents (sGABA~A~‐PSCs) were isolated in the presence of ionotropic glutamate receptor antagonists. A conditioning protocol relevant to the physiological condition, consisting of repetitive depolarizing pulses (DPs) at 0.1 Hz, was able to induce long‐lasting changes in both frequency and amplitude of sGABA~A~‐PSCs between P0 and P8. Starting from P12, DPs were unable to induce any form of synaptic plasticity. The effects of DPs were tightly keyed to the frequency at which they were delivered. When delivered at a lower (0.05 Hz) or higher (1 Hz) frequency, DPs failed to induce any long‐lasting change in the frequency or amplitude of sGABA~A~‐PSCs. In two cases, DPs were able to activate sGABA~A~‐PSCs in previously synaptically silent cells at P0–1. These results show that long‐term changes in GABAergic synaptic activity can be induced during a restricted period of development by a conditioning protocol relevant to the phy

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Author

Paolo Gubellini; Yehezkel Ben‐Ari; Jean‐Luc Gaïarsa

Publisher

John Wiley and Sons; Wiley (Blackwell Publishing); Blackwell Publishing Inc.; Wiley (ISSN 0953-816X)

Published

2001

Language

EN

Field

Neuroscience (Life Sciences)