Can I read Purification and Characterisation of Large and Small Maitotoxins from Cultured Gambierdiscus Toxicus on EtoBox?

Purification and Characterisation of Large and Small Maitotoxins from Cultured Gambierdiscus Toxicus by Dr. Michael J. Holmes; Richard J. Lewis is a Agricultural and Biological Sciences article available to read on EtoBox.

What is Purification and Characterisation of Large and Small Maitotoxins from Cultured Gambierdiscus Toxicus about?

Three strains of cultured Gambierdiscus toxicus yielded distinct maitotoxins (maitotoxin-I, -2, and -3) which were purified to homogeneity by high pressure liquid chromatography. Maitotoxins-1 and -2 are large toxins (molecular weights for the sodium salts = 3,422 and 3,298, respectively), whereas maito-toxin3 is relatively small (molecular weight = 1,060 for the sodium salt). The contractile actions on isolated guinea-pig left atria, vas deferens and ilea of maitotoxins-I and -2 were compared with those of the small maitotoxin, maitotoxin-3. Maitotoxin-1, -2, and -3 each produced quantitatively similar, concentration-dependent patterns of positive and negative inotropy in atria when compared on a mouse unit/ml basis (one mouse unit is the intraperitoneal LDso dose for a 20 g mouse; the I D, , for maitotoxin-2 = 0.08 pgfkg). Concentrations of maitotoxin-2 greater than 5 x M caused positive inotropy. The three maitotoxins produced patterns of contractions in vas deferens and ilea that were qualitatively similar, including a period of prominent spike activity in vas deferens. On a mouse unit/ml basis, the order of potency on smooth muscle was maitotoxin-I > maitotoxin-3 > maitotoxin-

Who reads Purification and Characterisation of Large and Small Maitotoxins from Cultured Gambierdiscus Toxicus?

Author

Dr. Michael J. Holmes; Richard J. Lewis

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 1056-9014)

Published

1994

Language

EN

ISBN

9782620020200

Field

Agricultural and Biological Sciences (Life Sciences)