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What is Shellac about?

This study investigates the use of shellac as a natural excipient in amorphous solid dispersions (ASDs) to enhance the solubility and maintain supersaturation of the poorly soluble drug loratadine. The research finds that a 10% weight fraction of shellac significantly improves solubility by 30-fold and maintains supersaturation for 3 hours, attributed to stronger interactions within the API matrix. The findings suggest that shellac, in combination with HPMC, could be beneficial for developing ASDs aimed at

Author

s4r4y20023

Language

EN