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## Background: Acquired glanzmann's thrombasthenia is a rare hemorrhagic diathesis resulting from impaired adhesive function of the platelet receptor gpiib/iiia (alpha(iib)beta3). typically, this disorder develops during adulthood, with patients manifesting fluctuating clinical and laboratory findings. to date, the underlying defect of most if not all cases of acquired glanzmann's thrombasthenia results from an autoantibody or plasma protein inhibitor directed toward a demonstrably normal gpiib/iiia glycoprotein. ## Methods: In this report, a patient with a history of treated hodgkin's lymphoma presented with a severe hemorrhagic diathesis characterized by mild thrombocytopenia, a prolonged bleeding time, and defective platelet aggregation. ## Results: Examination of the patient's platelet gpiib/iiia by western blot analysis revealed no abnormality. mixing studies demonstrated a non-immunoglobulin g plasma inhibitory factor, whereas flow cytometry analysis revealed elevated platelet-associated immunoglobulin (ig) m. after an emergency colectomy for severe hemorrhage, the patient's qualitative and quantitative platelet parameters significantly improved. pathology of the resected col

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Author

Umekalsoom Malik; Janice P. Dutcher; Leslie Oleksowicz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0008-543X)

Published

1998

Language

EN

Field

Medicine (Health Sciences)