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MicroRNAs associated with postoperative outcomes in patients with limited stage neuroendocrine carcinoma of the esophagus by Tomoyuki Okumura; Tsutomu Fujii; Kenji Terabayashi; Takashi Kojima; Shigeru Takeda; Tomomi Kashiwada; Kazuhiro Toriyama; Susumu Hijioka; Tatsuya Miyazaki; Miho Yamamoto; Shunsuke Tanabe; Yasuhiro Shirakawa; Masayuki Furukawa; Yoshitaka Honma; Isamu Hoshino; Yoshihiro Nabeya; Hironori Yamaguchi; Shinji Uemoto; Yutaka Shimada; Hisahiro Matsubara; Soji Ozawa; Hiroyasu Makuuchi; Masayuki Imamura is a scholarly article available to read on EtoBox.

What is MicroRNAs associated with postoperative outcomes in patients with limited stage neuroendocrine carcinoma of the esophagus about?

Esophageal neuroendocrine carcinoma (E-NEC) is an aggressive disease with a poor prognosis. The present study aimed to assess the role of surgery in the treatment of patients with resectable E-NEC, and identify a microRNA (miRNA/miR) signature in association with positive postoperative outcomes. Between February 2017 and August 2019, 36 patients with E-NEC who underwent curative surgery at the Japan Neuroendocrine Tumor Society partner hospitals were enrolled in the study. A total of 16 (44.4%) patients achieved disease-free survival (non-relapse group), whereas 20 (55.6%) patients developed tumor relapse (relapse group) during the median follow-up time of 36.5 months (range, 1–242) after surgery with a 5-year overall survival rate of 100 and 10.8%, respectively (P<0.01). No clinicopathological parameters, such as histological type or TNM staging, were associated with tumor relapse. Microarray analysis of 2,630 miRNAs in 11 patients with sufficient quality RNA revealed 12 miRNAs (miR-1260a, −1260b, −1246, −4284, −612, −1249-3p, −296-5p, −575, −6805-3p, −12136, −6822-5p and −4454) that were differentially expressed between the relapse (n=6) and non-relapse (n=5) groups. Furthermore,

Author

Tomoyuki Okumura; Tsutomu Fujii; Kenji Terabayashi; Takashi Kojima; Shigeru Takeda; Tomomi Kashiwada; Kazuhiro Toriyama; Susumu Hijioka; Tatsuya Miyazaki; Miho Yamamoto; Shunsuke Tanabe; Yasuhiro Shirakawa; Masayuki Furukawa; Yoshitaka Honma; Isamu Hoshino; Yoshihiro Nabeya; Hironori Yamaguchi; Shinji Uemoto; Yutaka Shimada; Hisahiro Matsubara; Soji Ozawa; Hiroyasu Makuuchi; Masayuki Imamura

Publisher

Spandidos Publications

Published

2023

Language

EN