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Bioinspired Reactive Interfaces Based on Layered Double Hydroxides-Zn Rich Hydroxyapatite with Antibacterial Activity by Anna Donnadio; Marzia Bini; Catia Centracchio; Maurizio Mattarelli; Silvia Caponi; Valeria Ambrogi; Donatella Pietrella; Alessandro Di Michele; Riccardo Vivani; Morena Nocchetti is a scholarly article available to read on EtoBox.

What is Bioinspired Reactive Interfaces Based on Layered Double Hydroxides-Zn Rich Hydroxyapatite with Antibacterial Activity about?

This work is focused on the preparation and multi-technique characterization of potentially biocompatible reactive interfaces obtained by combining layered double hydroxides (LDHs) and hydroxyapatite (HA). Antimicrobial and osteoinductive metallic ions as Zn 2+ and Ga 3+ were chosen as intralayer constituents of LDH to obtain ZnAl and ZnAlGa systems. These LDHs, exchanged with dihydrogenphosphate anions, promoted the precipitation of HA on the LDH surface yielding HA@LDH composites. X-ray diffraction quantitative analysis, through the Rietveld refinement method, coupled with elemental analysis and micro-Raman spectroscopy showed the formation of a mixed Ca-Zn HA phase. Scanning electron microscopy revealed that HA, in the presence of LDH, grew preferentially along its a-axis, thus crystallizing mainly in the form of flake crystals. LDH and HA@LDH composites showed antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa at not cytotoxic concentrations for human osteoblasts (hFob 1.19), especially when Ga cations were present in the LDH structure. The effect of the presence of HA in the composites on the bone-bonding ability and on human osteoblast proliferati

Author

Anna Donnadio; Marzia Bini; Catia Centracchio; Maurizio Mattarelli; Silvia Caponi; Valeria Ambrogi; Donatella Pietrella; Alessandro Di Michele; Riccardo Vivani; Morena Nocchetti

Publisher

American Chemical Society (ACS)

Published

2021

Language

EN