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HIV-1 Genetic Diversity in Russia: CRF63_02A1, a New HIV Type 1 Genetic Variant Spreading in Siberia by Pavel B. Baryshev; Vladislav V. Bogachev; Natalya M. Gashnikova is a Medicine article available to read on EtoBox.

What is HIV-1 Genetic Diversity in Russia: CRF63_02A1, a New HIV Type 1 Genetic Variant Spreading in Siberia about?

One of the factors determining a high degree of heterogeneity in the HIV population is recombination-based variation, which leads to the emergence of the virus variants with a mosaic genome. An example is CRF63\_02A1, an HIV-1 variant currently spreading in the Siberian region of Russia. To prove that this HIV-1 variant is a new circulating recombinant form that had emerged as a result of repeated recombination between CRF02\_AG and subtype A, we have isolated seven full-length HIV genomes and theoretically analyzed them, that is, reconstructed the phylogenetic relationships, determined recombination breakpoints and regions, and compared them with the regions known for CRF02\_AG.

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Author

Pavel B. Baryshev; Vladislav V. Bogachev; Natalya M. Gashnikova

Publisher

Mary Ann Liebert Inc

Published

2013

Language

EN

Field

Medicine (Life Sciences)