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Expression of phosphorylated raf kinase inhibitor protein (pRKIP) is a predictor of lung cancer survival by Sara Huerta-Yepez; Nam K Yoon; Angeles Hernandez-Cueto; Vei Mah; Clara M Rivera-Pazos; Devasis Chatterjee; Mario I Vega; Erin L Maresh; Steve Horvath; David Chia; Benjamin Bonavida; Lee Goodglick is a Medicine article available to read on EtoBox.
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## Background Raf-1 kinase inhibitor protein (RKIP) has been reported to negatively regulate signal kinases of major survival pathways. RKIP activity is modulated in part by phosphorylation on Serine 153 by protein kinase C, which leads to dissociation of RKIP from Raf-1. RKIP expression is low in many human cancers and represents an indicator of poor prognosis and/or induction of metastasis. The prognostic power has typically been based on total RKIP expression and has not considered the significance of phospho-RKIP. ## Methods The present study examined the expression levels of both RKIP and phospho-RKIP in human lung cancer tissue microarray proteomics technology. ## Results Total RKIP and phospho-RKIP expression levels were similar in normal and cancerous tissues. phospho-RKIP levels slightly decreased in metastatic lesions. However, the expression levels of phospho-RKIP, in contrast to total RKIP, displayed significant predictive power for outcome with normal expression of phospho-RKIP predicting a more favorable survival compared to lower levels (P = 0.0118); this was even more pronounced in more senior individuals and in those with early stage lung cancer. ## Conclusions Thi
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- Author
- Sara Huerta-Yepez; Nam K Yoon; Angeles Hernandez-Cueto; Vei Mah; Clara M Rivera-Pazos; Devasis Chatterjee; Mario I Vega; Erin L Maresh; Steve Horvath; David Chia; Benjamin Bonavida; Lee Goodglick
- Publisher
- BioMed Central; Springer (Biomed Central Ltd.); London: BioMed Central, [2001]-; Springer Science and Business Media LLC; Society for Mining, Metallurgy and Exploration Inc. (ISSN 1471-2407)
- Published
- 2011
- Language
- EN
- ISBN
- 9781471240713
- Field
- Medicine (Health Sciences)