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Can I read miR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR on EtoBox?
miR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR by Tang, Yong-Jing (author);Wu, Wei (author);Chen, Qiao-Qian (author);Liu, Shu-Han (author);Zheng, Zhi-Yuan (author);Cui, Zhao-Lei (author);Xu, Jian-Ping (author);Xue, Yan (author);Lin, Dong-Hong (author) is a Medicine article available to read on EtoBox.
What is miR-29b-3p suppresses the malignant biological behaviors of AML cells via inhibiting NF-κB and JAK/STAT signaling pathways by targeting HuR about?
## Background: Hur/elavl1 (embryonic lethal abnormal vision 1) was a downstream target of mir-29b in some cancer cells. hur protein exerts important prognostic effects of involving in the pathogenesis and development of acute myeloid leukemia (aml). this study aims to investigate the role of mir-29b-3p in biological behaviors of aml cells by targeting hur and the involvement of the nf-κb and jak/stat signaling pathways. ## Methods: The expressions of hur and mir-29b-3p in aml cells were determined using rt-qpcr and western blot, and the association between them was analyzed using the spearman method. next, the target relationship between hur and mir-29b-3p was predicted by biological information databases and verified by the dual-luciferase reporter gene assay. mts, methyl cellulose, flow cytometry and transwell assay were employed to detect the cell proliferation, clone formation, cell cycle and apoptosis, invasion and migration respectively, the effect of mir-29b-3p targeted hur on the biological behaviors of aml cells was explored after over- /down-expression of mir-29b-3p and rescue experiment. then, immunofluorescence assay and western blot were employed to detect location exp
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- Author
- Tang, Yong-Jing (author);Wu, Wei (author);Chen, Qiao-Qian (author);Liu, Shu-Han (author);Zheng, Zhi-Yuan (author);Cui, Zhao-Lei (author);Xu, Jian-Ping (author);Xue, Yan (author);Lin, Dong-Hong (author)
- Publisher
- Springer Science and Business Media LLC
- Published
- 2022
- Language
- EN
- Field
- Medicine (Health Sciences)