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MTORC1 Promotes Cell Growth Via m6A-Dependent MRNA Degradation by smolinegoralexeyevich is a document available to read on EtoBox.
The study investigates the role of mTORC1 in promoting cell growth through m6A-dependent mRNA degradation, specifically highlighting the regulation of WTAP, a key component of the m6A methyltransferase complex. It demonstrates that mTORC1 enhances WTAP translation via eIF4A/4B, leading to increased m6A modification of MXD2 mRNA, which in turn promotes cMyc activity and tumor growth. These findings suggest that targeting the WTAP-MXD2-cMyc axis could be a potential therapeutic strategy for mTORC1-driven canc
- Author
- smolinegoralexeyevich
- Language
- EN