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Efficacy and safety of granulocyte macrophage-colony stimulating factor (GM-CSF) on the frequency and severity of radiation mucositis in patients with head and neck carcinoma by V. Kannan; Poonamallee P. Bapsy; Naranappa Anantha; Dinesh Chandra Doval; Hema Vaithianathan; G. Banumathy; Krishnamurthy B. Reddy; Saklaspur Veerappaiah Kumaraswamy; Ashok Mohan Shenoy is a Medicine article available to read on EtoBox.

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## Purpose: Based on the clinical evidence of mucosal protection by gm-csf during cytotoxic chemotherapy, a pilot study was undertaken to determine the safety and mucosal reaction of patients receiving gm-csf while undergoing definitive conventional fractionated radiotherapy in head and neck carcinoma. ## Methods and materials: Patients were considered eligible if buccal mucosa and oropharynx were included in the teleradiation field. ten adult patients with squamous cell carcinoma of head and neck (buccal mucosa--8 and posterior 1/3 tongue--2) were entered into the trial. radiation therapy was delivered with telecobalt machine at conventional 2 gy fraction and 5 fractions/week. the radiation portals consisted of two parallel opposing lateral fields. gm-csf was given subcutaneously at a dose of 1 microg/kg body weight, daily, after 20 gy until the completion of radiation therapy. patients were evaluated daily for mucosal reaction, pain, and functional impairment. ## Results: The median radiation dose was 66 gy. eight patients received > or = 60 gy. the tolerance to gm-csf was good. all 10 patients completed the planned daily dose of gm-csf without interruption. mucosal toxicity was

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Author

V. Kannan; Poonamallee P. Bapsy; Naranappa Anantha; Dinesh Chandra Doval; Hema Vaithianathan; G. Banumathy; Krishnamurthy B. Reddy; Saklaspur Veerappaiah Kumaraswamy; Ashok Mohan Shenoy

Publisher

Elsevier Science; Elsevier ; Elsevier BV (ISSN 0360-3016)

Published

1997

Language

EN

Field

Medicine (Health Sciences)