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SARS-CoV-2 rapid antigen test: High sensitivity to detect infectious virus by Johan Nordgren; Sumit Sharma; Henrik Olsson; Mikael Jämtberg; Tina Falkeborn; Lennart Svensson; Marie Hagbom is a Medicine article available to read on EtoBox.

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## Background: The covid-19 pandemic has highlighted the need for rapid, cost effective and easy-to-use diagnostic tools for sars-cov-2 infections that can be used in point of care settings to limit disease transmission. ## Objective: We evaluated two rapid antigen immunochromatographic tests, abbott panbioTM covid-19 ag rapid test (panbio) and zhejiang orient gene/healgen biotech coronavirus ag rapid test cassette (orient gene) for detection of infectious sars-cov-2. ## Results: The tests were evaluated on nasopharyngeal samples taken from individuals having respiratory and/or covid-19 related symptoms, which had been analyzed for sars-cov-2 rna using real-time pcr. in total 156 pcr-positive, and 130 (panbio) and 176 (orient gene) pcr-negative samples were analyzed. overall sensitivity and specificity were 71.8% and 100% for panbio and 79.5% and 74.4% for the orient gene test respectively. the false positives by the orient gene test were verified as sars-cov-2 negative by in-house real-time pcr assay and were negative for the four seasonal coronaviruses. subgroup analysis revealed that the antigen tests had high sensitivity for samples with ct-values 88%) and for samples containi

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Author

Johan Nordgren; Sumit Sharma; Henrik Olsson; Mikael Jämtberg; Tina Falkeborn; Lennart Svensson; Marie Hagbom

Publisher

Elsevier BV

Published

2021

Language

EN

Field

Medicine (Health Sciences)