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Epidemiology of Down syndrome (Trisomy 21), Hawaii, 1986–97 by Mathias B. Forrester; Ruth D. Merz is a Medicine article available to read on EtoBox.

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## Abstract ## Background The live birth prevalence of Down syndrome is approximately 10 per 10,000 live births in the United States. Down syndrome prevalence has been reported to change over time and to vary by selected demographic factors. ## Methods Data from a population‐based birth defects registry in Hawaii involving 363 Down syndrome cases delivered during 1986–97 were used to calculate overall prevalence and to investigate secular trends and differences by selected demographic factors. ## Results The total (live birth, fetal death, and elective termination) prevalence was 14.74 per 10,000 live births and fetal deaths. The unadjusted live birth prevalence was 8.67 per 10,000 live births. The adjusted live birth (live births and proportion of elective terminations expected to have resulted in live births) prevalence was 12.59 per 10,000 live births. No significant secular trends were observed for either total prevalence (__P__ = 0.688) or adjusted live birth prevalence (__P__ = 0.604). The total Down syndrome prevalence per 10,000 live births was highest for Far East Asians (22.01), followed by whites (17.06), Filipinos (15.94), and Pacific Islanders (9.21). Prevalence per 10

Who reads Epidemiology of Down syndrome (Trisomy 21), Hawaii, 1986–97?

Author

Mathias B. Forrester; Ruth D. Merz

Publisher

John Wiley and Sons; Wiley (John Wiley & Sons); John Wiley & Sons Inc.; Wiley (ISSN 0040-3709)

Published

2002

Language

EN

Field

Medicine (Health Sciences)